Really it depends on the host application you are running, but generally speaking it's not a good idea to run a stripe on top of a stripe.  If you want to do host striping on meta volumes, you can, but it's best to uses a concatenated meta volume rather than a striped one.  But also consider if you're using thin devices. Thin devices are already striped on the back-end,  so you usually are fine using concatenated meta devices (but not always, depending on performance requirements)..

Also keep in mind SRDF limitations.. If you're running SRDF/Sync you'll need to uses striped luns as to avoid a performance problem where-by you have limited write concurrency..

Out of curiosity,  why are you looking at host striping?